2,5-二(羟基甲基)-3,4-吡咯烷二醇合成路线 （共 53 条）
反应条件
1: 30 percent / pyridine / CH2Cl2
2: 99 percent / acetic acid, water
3: 76 percent / imidazole, / dimethylformamide
4: 95 percent / pyridine / CH2Cl2
5: 99 percent / H2 / palladium black / ethyl acetate
6: 74 percent / sodium acetate / methanol
7: lithium triethylborohydride / tetrahydrofuran
8: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 85 percent / pyridine / CH2Cl2
2: 99 percent / acetic acid, water
3: 76 percent / imidazole, / dimethylformamide
4: 95 percent / pyridine / CH2Cl2
5: 99 percent / H2 / palladium black / ethyl acetate
6: 74 percent / sodium acetate / methanol
7: lithium triethylborohydride / tetrahydrofuran
8: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 75 percent / pyridine / CH2Cl2
2: 84 percent / acetic acid, water
3: 71 percent / imidazole / dimethylformamide
4: 95 percent / pyridine / CH2Cl2
5: 86 percent / 1.) H2; 2.) sodium acetate / 1.) palladium black / 1.) ethyl acetate; 2.) acetonitrile
6: lithium triethylborohydride / tetrahydrofuran
7: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 91 percent / camphor sulfonic acid
2: 75 percent / pyridine / CH2Cl2
3: 84 percent / acetic acid, water
4: 71 percent / imidazole / dimethylformamide
5: 95 percent / pyridine / CH2Cl2
6: 86 percent / 1.) H2; 2.) sodium acetate / 1.) palladium black / 1.) ethyl acetate; 2.) acetonitrile
7: lithium triethylborohydride / tetrahydrofuran
8: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 71 percent / imidazole / dimethylformamide
2: 95 percent / pyridine / CH2Cl2
3: 86 percent / 1.) H2; 2.) sodium acetate / 1.) palladium black / 1.) ethyl acetate; 2.) acetonitrile
4: lithium triethylborohydride / tetrahydrofuran
5: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 76 percent / imidazole, / dimethylformamide
2: 95 percent / pyridine / CH2Cl2
3: 99 percent / H2 / palladium black / ethyl acetate
4: 74 percent / sodium acetate / methanol
5: lithium triethylborohydride / tetrahydrofuran
6: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 84 percent / acetic acid, water
2: 71 percent / imidazole / dimethylformamide
3: 95 percent / pyridine / CH2Cl2
4: 86 percent / 1.) H2; 2.) sodium acetate / 1.) palladium black / 1.) ethyl acetate; 2.) acetonitrile
5: lithium triethylborohydride / tetrahydrofuran
6: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 99 percent / acetic acid, water
2: 76 percent / imidazole, / dimethylformamide
3: 95 percent / pyridine / CH2Cl2
4: 99 percent / H2 / palladium black / ethyl acetate
5: 74 percent / sodium acetate / methanol
6: lithium triethylborohydride / tetrahydrofuran
7: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 95 percent / pyridine / CH2Cl2
2: 86 percent / 1.) H2; 2.) sodium acetate / 1.) palladium black / 1.) ethyl acetate; 2.) acetonitrile
3: lithium triethylborohydride / tetrahydrofuran
4: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 95 percent / pyridine / CH2Cl2
2: 99 percent / H2 / palladium black / ethyl acetate
3: 74 percent / sodium acetate / methanol
4: lithium triethylborohydride / tetrahydrofuran
5: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
