2,5-二(羟基甲基)-3,4-吡咯烷二醇合成路线 （共 53 条）
反应条件
1: 86 percent / 1.) H2; 2.) sodium acetate / 1.) palladium black / 1.) ethyl acetate; 2.) acetonitrile
2: lithium triethylborohydride / tetrahydrofuran
3: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 99 percent / H2 / palladium black / ethyl acetate
2: 74 percent / sodium acetate / methanol
3: lithium triethylborohydride / tetrahydrofuran
4: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: culture of Gluconobactor cerinus (ATCC catalogue number IFO 3267)
2: NaBH4
3: H2 / hydrogenation catalyst
View Scheme
参考文献
Yu, Jaehoon; Choi, So Young; Lee, Sungsoo; Yoon, Hyun Joo; Jeong, Sunjoo; Mun, Hansuh; Park, Hokoon; Schultz, Peter G.
Chemical Communications, 1997 , # 20 p. 1957 - 1958
反应条件
hydrogen; potassium carbonate; palladium
1.) AcOH; 2.) MeOH, reflux; Yield given. Multistep reaction;
参考文献
McCort, Isabelle; Dureault, Annie; Depezay, Jean-Claude
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7717 - 7720
反应条件
hydrogen; potassium carbonate; palladium
1.) AcOH; 2.) MeOH, reflux; Yield given. Multistep reaction;
参考文献
McCort, Isabelle; Dureault, Annie; Depezay, Jean-Claude
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7717 - 7720
反应条件
1.1: Li2NiBr4 / tetrahydrofuran / 0 - 4 °C
1.2: 75 percent / AgNO3 / dimethylformamide / 9 h / 70 °C
2.1: 83 percent / CH2Cl2 / 2 h / 0 °C
3.1: isoamyl nitrite; Et3N / tetrahydrofuran / 1.5 h / Heating
3.2: hydrogen / Pd black / acetic acid / 20 °C / 760 Torr
3.3: K2CO3 / methanol / Heating
View Scheme
参考文献
McCort, Isabelle; Fort, Sebastien; Dureault, Annie; Depezay, Jean-Claude
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 135 - 143
反应条件
1.1: 83 percent / CH2Cl2 / 2 h / 0 °C
2.1: isoamyl nitrite; Et3N / tetrahydrofuran / 1.5 h / Heating
2.2: hydrogen / Pd black / acetic acid / 20 °C / 760 Torr
2.3: K2CO3 / methanol / Heating
View Scheme
参考文献
McCort, Isabelle; Fort, Sebastien; Dureault, Annie; Depezay, Jean-Claude
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 135 - 143
反应条件
1: lithium triethylborohydride / tetrahydrofuran
2: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: lithium triethylborohydride / tetrahydrofuran
2: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
反应条件
1: 74 percent / sodium acetate / methanol
2: lithium triethylborohydride / tetrahydrofuran
3: 1percent HCl / methanol
View Scheme
参考文献
Long, Daniel D.; Frederiksen, Signe M.; Marquess, Daniel G.; Lane, Alexandra L.; Watkin, David J.; Winkler, David A.; Fleet, George W. J.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 6091 - 6094
