2,5-二(羟基甲基)-3,4-吡咯烷二醇合成路线 （共 53 条）
反应条件
Dowex 50W-X8; hydrogen; triethylamine; palladium on activated charcoal
Yield given. Multistep reaction;
参考文献
Park, Ki Hun
Heterocycles, 1995 , vol. 41, # 8 p. 1715 - 1720
反应条件
1.1: dichloromethane / 1 h / 20 °C
2.1: water / 1,4-dioxane / 16 h / 20 °C
2.2: 16 h / 0 - 20 °C
3.1: hydrogenchloride / diethyl ether / 0.17 h / 20 °C
4.1: palladium hydroxide on carbon; hydrogen / methanol / 48 h / 20 °C / 3800.26 Torr
View Scheme
参考文献
Davies, Stephen G.; Figuccia, Aude L.A.; Fletcher, Ai M.; Roberts, Paul M.; Thomson, James E.
Tetrahedron, 2014 , vol. 70, # 22 p. 3601 - 3607
反应条件
1: 34 mg / aq. NaOH; NaBH3CN / 4 - 25 °C / pH 6 - 7
2: aq. sodium acetate buffer; acid phosphatase / 72 h / 37 °C / pH 4.8
View Scheme
参考文献
Schuster, Matthias; Blechert, Siegfried
Tetrahedron Asymmetry, 1999 , vol. 10, # 16 p. 3139 - 3145
