1: 42 percent / sodium hydride / dimethylformamide / 140 °C 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 3: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 2.) DMF View Scheme

1: 42 percent / sodium hydride / dimethylformamide / 140 °C 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 3: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 2.) DMF View Scheme

1: 42 percent / sodium hydride / dimethylformamide / 140 °C 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 3: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 2 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 84 percent / pyridine / cyclohexane; dioxane / Ambient temperature<br />2: 91 percent / xylene / 2 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 84 percent / pyridine / cyclohexane; dioxane / Ambient temperature<br />2: 91 percent / xylene / 2 h / Heating<br /> <br /> &nbsp;