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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
132312-57-3
合成路线
（共 12 条）
591-17-3
3-溴甲基苯
+
126747-14-6
4-氰基苯硼酸
→
反应条件
132312-57-3
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; N,N-dimethyl-formamide T=80°C; Suzuki Coupling; 17 h;
参考文献
PFIZER INC.
Patent: WO2006/134481 A1, 2006 ;
Location in patent: Page/Page column 27 ;
17933-03-8
3-甲基苯硼酸
+
126747-14-6
4-氰基苯硼酸
→
反应条件
132312-57-3
反应条件
1: (4-cyano-phenyl)boronic acid With iodine; potassium carbonate in acetonitrile T=80°C; 8 h; Inert atmosphereSchlenk techniqueSealed tube; 2: 3-methyl phenyl boronic acid With palladium diacetate in acetonitrile T=80°C; Suzuki Coupling; 12 h; Inert atmosphereSchlenk techniqueSealed tube;
参考文献
Niu, Liting; Zhang, Hao; Yang, Haijun; Fu, Hua
Synlett, 2014 , vol. 25, # 7 art. no. 691, p. 995 - 1000
17933-03-8
3-甲基苯硼酸
+
873-74-5
对氨基苯腈
→
反应条件
132312-57-3
反应条件
1: p-aminobenzonitrile With tert.-butylnitrite; acetic acid in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: 3-methyl phenyl boronic acid With tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane in N,N-dimethyl-formamide T=90°C; 10 h; Inert atmosphere;
参考文献
Mo, Fanyang; Qiu, Di; Jiang, Yubo; Zhang, Yan; Wang, Jianbo
Tetrahedron Letters, 2011 , vol. 52, # 4 p. 518 - 522
21436-44-2
3-甲基苯-1-羧酸酐
→
反应条件
反应条件
potassium fluoride; tetrakis-(ethylene)-μ,μ'-dichlorodirhodium(I) in 1,3,5-trimethyl-benzene T=160°C; Suzuki coupling; 8 h;
参考文献
Goossen; Paetzold
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1665 - 1668
623-03-0
对氯苯甲腈
+
16419-60-6
2-甲基苯硼酸
→
反应条件
132312-57-3
反应条件
tripotassium phosphate monohydrate; 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole; palladium diacetate in 1,4-dioxane; 1,3,5-trimethyl-benzene T=135°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Wong, Shun Man; So, Chau Ming; Chung, Kin Ho; Lau, Chak Po; Kwong, Fuk Yee
European Journal of Organic Chemistry, 2012 , # 22 p. 4172 - 4177
→
反应条件
132312-57-3
反应条件
5 palladium on charcoal; potassium carbonate in ethanol; water T=20°C; Suzuki Coupling; 0.666667 h;
参考文献
Liu, Chun; Rao, Xiaofeng; Zhang, Yixia; Li, Xinmin; Qiu, Jieshan; Jin, Zilin
European Journal of Organic Chemistry, 2013 , # 20 p. 4345 - 4350
3058-39-7
4-碘氰基苯
+
26919-48-2
→
反应条件
132312-57-3
反应条件
potassium acetate; palladium diacetate; N,N-dicyclohexylamine in N,N-dimethyl-formamide T=35°C; 2 h; Inert atmosphere;
参考文献
Rao, Maddali L.N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6101 - 6104
17933-03-8
3-甲基苯硼酸
+
36800-95-0
→
反应条件
132312-57-3
反应条件
potassium phosphate; BF4(1-)*C31H33ClN5Ni(1+) in ethylene glycol dimethyl ether T=120°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphereSealed tube;
参考文献
Kuroda, Jun-Ichi; Inamoto, Kiyofumi; Hiroya, Kou; Doi, Takayuki
European Journal of Organic Chemistry, 2009 , # 14 p. 2251 - 2261
3058-39-7
4-碘氰基苯
+
17933-03-8
3-甲基苯硼酸
→
反应条件
132312-57-3
反应条件
potassium phosphate in carbonic acid dimethyl ester T=135°C; Inert atmosphere;
参考文献
Inamoto, Kiyofumi; Hasegawa, Chisa; Hiroya, Kou; Kondo, Yoshinori; Osako, Takao; Uozumi, Yasuhiro; Doi, Takayuki
Chemical Communications, 2012 , vol. 48, # 23 p. 2912 - 2914
→
反应条件
132312-57-3
反应条件
caesium carbonate; palladium dichloride in N,N-dimethyl-formamide T=185°C; 20 h; Inert atmosphereSealed tube;
参考文献
Ortgies, Dirk H.; Forgione, Pat
Synlett, 2013 , vol. 24, # 13 art. no. ST-2013-S0280-L, p. 1715 - 1721
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