dicyclohexyl-carbodiimide

1: Fmoc-Gly-Novasynreg; TGT resin With piperidine in N,N-dimethyl-formamide T=20°C; 0.333333 h; solid phase reaction; 2: Nα-Fmoc-N(im)-trityl-L-histidine With n-ethyl morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in N,N-dimethyl-formamide 2 h; solid phase reaction; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; fmoc-L-Ser(TBu)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine Further stages;

1: Fmoc-Gly-Novasynreg; TGT resin With piperidine in N,N-dimethyl-formamide T=20°C; 0.333333 h; solid phase reaction; 2: Nα-Fmoc-N(im)-trityl-L-histidine With n-ethyl morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in N,N-dimethyl-formamide 2 h; solid phase reaction; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; fmoc-L-Ser(TBu)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine Further stages;

1: Fmoc-Arg(Pbf)-Wang polystyrene resin With piperidine in N,N-dimethyl-formamide solid phase reaction; 2: fmoc-L-Ser(TBu)-OH With benzotriazol-1-ol; diisopropyl-carbodiimide in N,N-dimethyl-formamide 2 h; solid phase reaction; 3: Fmoc-L-phenylalanine; fmoc-Gln(Trt)-OH; fmoc-L-Arg(Pbf)-OH Further stages;

1: fmoc-L-Arg(Pbf)-OH With N-ethyl-N,N-diisopropylamine in dichloromethane solid phase reaction; 2: With piperidine in N,N-dimethyl-formamide 0.166667 h; solid phase reaction; 3: Fmoc-L-phenylalanine; fmoc-L-Ser(TBu)-OH; fmoc-Gln(Trt)-OH; fmoc-L-Arg(Pbf)-OH Further stages;

1: Fmoc-Arg(Pmc)-Sasrin resin With piperidine in N,N-dimethyl-formamide solid phase reaction; 2: 9-fluorenylmethyloxycarbonyl-D-Ser(t-butyl)-OH With benzotriazol-1-ol; diisopropyl-carbodiimide in N,N-dimethyl-formamide 3: Fmoc-L-phenylalanine; fmoc-Gln(Trt)-OH; Fmoc-Arg(Pmc)-OH Further stages;

1: N-Fmoc-D-Tyr(t-Bu)-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine TentaGel RRAM solid phase resin; 2: With piperidine in N,N-dimethyl-formamide T=50°C; 1 h; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; Fmoc-O-trityl-l-threonine; fmoc-Asn(trt)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine; Fmoc-Asp(OMpe)-OH; N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH; fmoc-L-Arg(Pbf)-OH Further stages;