1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane 2: N-ethyl-N,N-diisopropylamine / methanol / 2 h 3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h 4: 4 h 5: pH 5 View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 21 &deg;C<br />2: toluene-4-sulfonic acid / dichloromethane; methanol / 21 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3570522', constants.ctx, '0')">tetrabutyl ammonium fluoride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <br /> <br /> &nbsp;