S-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩)-丙胺合成路线 （共 21 条）
反应条件
1: (s)-(-)-N,N-dimethyl-3-(thien-2-yl)-3-hydroxy-propanamine With sodium hydride in dimethyl sulfoxide T=30 - 35°C; 0.5 h; 2: 4-fluoro-l-naphthalene in dimethyl sulfoxide T=60 - 65°C; 6 - 8 h; Product distribution / selectivity;
参考文献
WO2008/93360 A2, ;
Page/Page column 14-15 ;
反应条件
ammonia in water; toluene T=25 - 30°C; pH=9; 0.5 h;
参考文献
WO2006/27798 A2, ;
Page/Page column 19; 20 ;
反应条件
potassium hydroxide in water T=30 - 40°C;
参考文献
EP1857451 A1, ;
Page/Page column 5 ;
反应条件
ammonia in water; toluene T=25°C; 0.333333 - 0.5 h;
参考文献
US2007/173540 A1, ;
Page/Page column 3-4 ;
反应条件
ammonia in water; toluene T=25°C; 0.333333 - 0.5 h;
参考文献
US2007/173541 A1, ;
Page/Page column 6 ;
反应条件
ammonium hydroxide in water; toluene T=25°C; 0.333333 - 0.5 h;
参考文献
WO2007/86948 A1, ;
Page/Page column 15 ;
反应条件
1: (s)-(-)-N,N-dimethyl-3-(thien-2-yl)-3-hydroxy-propanamine With sodium hydride in dimethyl sulfoxide T=10 - 25°C; 1 h; 2: With KOC(O)Ph in dimethyl sulfoxide T=25°C; 0.5 h; 3: 4-fluoro-l-naphthalene With hydrogenchloride; sodium hydroxide; acetic acid more than 3 stages;
参考文献
WO2008/4191 A2, ;
Page/Page column 7-8 ;
反应条件
ammonium hydroxide in water; toluene T=25°C; 0.333333 - 0.5 h;
参考文献
WO2006/71868 A2, ;
Page/Page column 19 ;
反应条件
ammonium hydroxide in water; toluene T=25°C; 0.333333 - 0.5 h;
参考文献
WO2007/38253 A2, ;
Page/Page column 19 ;
反应条件
1: (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N,N-dimethylamine With sodium hydroxide in dimethyl sulfoxide T=10 - 30°C; 1 h; 2: 4-fluoro-l-naphthalene in dimethyl sulfoxide T=70 - 75°C; 20 h; Product distribution / selectivity;
参考文献
WO2009/19719 A2, ;
Page/Page column 18-20 ;
