S-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩)-丙胺合成路线 （共 21 条）
反应条件
potassium tert-butylate; tetrabutylammomium bromide in dimethyl sulfoxide T=90°C; optical yield given as percent ee;
参考文献
Organic Process Research and Development, , vol. 13, # 5 p. 854 - 856
反应条件
ammonia; water in dichloromethane pH=10.8; 0.25 - 0.5 h; Product distribution / selectivity;
参考文献
WO2008/107911 A2, ;
Page/Page column 22 ;
反应条件
ammonia; water in dichloromethane pH=10.8; 0.25 - 0.5 h; Product distribution / selectivity;
参考文献
WO2008/107911 A2, ;
Page/Page column 24 ;
反应条件
1.1: sodium hydride / dimethyl sulfoxide / 20 °C 1.2: 48 - 50 °C 1.3: 5 h / 20 °C 2.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12 View Scheme
反应条件
1.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 2 h / 35 - 40 °C 2.1: sodium hydride / dimethyl sulfoxide / 20 °C 2.2: 48 - 50 °C 2.3: 5 h / 20 °C 3.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12 View Scheme
反应条件
1: Resolution of racemate; 2: With water Basic aqueous solution; Purification / work up;
参考文献
US2008/287693 A1, ;
Page/Page column 3 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine; phenyl chloroformate in toluene T=60 - 80°C; 2 h; 2: With potassium hydroxide in ethanol; water 2 h; Heating / reflux;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2006/126213 A1, 2006 ;
Location in patent: Page/Page column 5; 9-10 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine; phenyl chloroformate in toluene T=60 - 80°C; 2 h; 2: With potassium hydroxide in ethanol; water 2 h; Heating / reflux;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2006/126213 A1, 2006 ;
Location in patent: Page/Page column 5; 9-10 ;
反应条件
in isopropanol acetate; water T=20°C; 21 h; Product distribution / selectivity;
参考文献
Medichem S.A.
Patent: US2009/93645 A1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
in ethyl acetate T=20°C; 1 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/86948 A1, 2007 ;
Location in patent: Page/Page column 15 ;
