(S)-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺草酸盐合成路线 （共 13 条）
反应条件
hydrogenchloride; formic acid; triethylamine; zinc; β,β,β-trichloroethoxycarbonylchloride 1) toluene, 30 min, 25 deg C 2) DMF; Yield given. Multistep reaction;
参考文献
Deeter, Jack; Frazier, Jeff; Staten, Gilbert; Staszak, Mike; Weigel, Leland
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 7101 - 7104
反应条件
ammonium hydroxide in water; toluene T=25°C; 0.333333 - 0.5 h;
参考文献
WO2006/71868 A2, ;
Page/Page column 19 ;
反应条件
1: With ammonia in water; toluene T=40°C; 0.166667 h; 2: With N-ethyl-N,N-diisopropylamine; phenyl chloroformate in toluene T=55°C; 1.25 h; 3: With hydrogenchloride; sodium hydrogencarbonate Product distribution / selectivity; more than 3 stages;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; TRIVEDI, Archana; KHARBANDA, Manlta; DUBEY, Shailendra; SINGLA, Sandeep; YOGIRAJ, Mansukhlal, Bodheka; VIR, Dharam
Patent: WO2011/33366 A2, 2011 ;
