(S)-N1-[(3-羟基-2-二羟基磷酰基甲氧基）丙基]-N4-胞嘧啶合成路线 （共 5 条）
反应条件
trimethylsilyl bromide in acetonitrile
参考文献
Holy, Antonin
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 3 p. 649 - 674
反应条件
trimethylsilyl bromide in dichloromethane 18 h; Ambient temperature;
参考文献
UNIVERSITY OF SOUTHERN CALIFORNIA (LA)
Patent: WO2006/14429 A2, 2006 ;
Location in patent: Page/Page column 11; figure 3 ;
WO 2006/014429 A2
反应条件
1: NaOH / dimethylformamide / 5 h / 105 °C 2: NaH / dimethylformamide / 6 h / 0 °C 3: HCl(g) / CH2Cl2 / 0.17 h / 0 - 5 °C 4: TMSBr / CH2Cl2 / 18 h / Ambient temperature View Scheme
参考文献
Brodfuehrer, Paul R.; Howell, Henry G.; Sapino, Chester Jr.; Vemishetti, Purushotham
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3243 - 3246
反应条件
1: HCl(g) / CH2Cl2 / 0.17 h / 0 - 5 °C 2: TMSBr / CH2Cl2 / 18 h / Ambient temperature View Scheme
参考文献
Brodfuehrer, Paul R.; Howell, Henry G.; Sapino, Chester Jr.; Vemishetti, Purushotham
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3243 - 3246
反应条件
ammonium hydroxide 4 h; Ambient temperature; Yield given;
参考文献
UNIVERSITY OF SOUTHERN CALIFORNIA (LA)
Patent: WO2006/14429 A2, 2006 ;
Location in patent: Page/Page column 11; figure 3 ;
WO 2006/014429 A2
