9-叠氮基-11-乙基-6-甲基吡啶并[3,2-c][1,5]苯并二氮杂卓-5-酮合成路线 （共 5 条）
反应条件
hydrogenchloride; sodium azide; sodium nitrite 1.) water, 5 deg C, 20 min, 2.) water, 15 min; Yield given. Multistep reaction;
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
2: 1.) dimsyl sodium / 1.) DMSO, 20 min, 2.) DMSO, 20 min 3: 45 percent / HOAc, SnCl2*2H2O, concd. HCl / 6 h / Ambient temperature 4: 1.) concd. HCl, NaNO2, 2.) NaN3 / 1.) water, 5 deg C, 20 min, 2.) water, 15 min View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
1: 1.) dimsyl sodium / 1.) DMSO, 20 min, 2.) DMSO, 20 min 2: 45 percent / HOAc, SnCl2*2H2O, concd. HCl / 6 h / Ambient temperature 3: 1.) concd. HCl, NaNO2, 2.) NaN3 / 1.) water, 5 deg C, 20 min, 2.) water, 15 min View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
1: 45 percent / HOAc, SnCl2*2H2O, concd. HCl / 6 h / Ambient temperature 2: 1.) concd. HCl, NaNO2, 2.) NaN3 / 1.) water, 5 deg C, 20 min, 2.) water, 15 min View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
2: 1.) dimsyl sodium / 1.) DMSO, 20 min, 2.) DMSO, 20 min 3: 45 percent / HOAc, SnCl2*2H2O, concd. HCl / 6 h / Ambient temperature 4: 1.) concd. HCl, NaNO2, 2.) NaN3 / 1.) water, 5 deg C, 20 min, 2.) water, 15 min View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
