反应条件
1: 1.) trimethylaluminum / 1.) CH2Cl2, hexane, RT, 20 min, 2.) CH2Cl2, hexane, 40 deg C, 40 h 2: 68 percent / pyridinium chlorochromate / CH2Cl2 / 48 h / Ambient temperature 3: 80 percent / K2CO3 / methanol / 24 h / Ambient temperature 4: 76 percent / 8N Jones' reagent / acetone / 2 h / 0 - 5 °C 5: 46 percent / DDC, DMAP / CH2Cl2; dimethylformamide / 72 h / Ambient temperature View Scheme
参考文献
Martin, Stephen F.; Austin, Richard E.; Oalmann, Christopher J.; Baker, William R.; Condon, Stephen L.; et al.
Journal of Medicinal Chemistry, 1992 , vol. <10> 35, # 35 p. 1710 - 1721
