N-[5-[N-[(3,4-二氢-2-甲基-4-氧-6-喹唑啉基)甲基]-N-甲基氨基]-2-噻吩甲酰]-L-谷氨酸二乙酯合成路线 （共 13 条）
反应条件
1: 55.8 percent / diphenylphosphoryl azide; triethylamine / 7 h / Heating 2: 90.4 percent / tetrabutylammonium bromide; K2CO3; NaOH / ethyl acetate / 0.17 h / 20 °C 3: 91.1 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 4: 74.2 percent / 2,6-lutidine / dimethylformamide / 55 - 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
1: 90.4 percent / tetrabutylammonium bromide; K2CO3; NaOH / ethyl acetate / 0.17 h / 20 °C 2: 91.1 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 3: 74.2 percent / 2,6-lutidine / dimethylformamide / 55 - 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
sodium hydroxide in ethanol T=20°C; 2 h;
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
