(R)-2-(2-吡咯烷基)乙酸甲酯合成路线 （共 13 条）
反应条件
silver benzoate; triethylamine T=-25 - 20°C; Rearrangement; Arndt-Eistert homologation; 3 h;
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
反应条件
(S,S)-1,3-dimethyl-4,5-(Ph2PCH2)2-imidazolidin-2-one; hydrogen; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in dichloromethane T=20°C; P=760 Torr; 12 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 14 p. 2209 - 2212
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Liu, Chang-Lu; Wei, Chang-Yong; Wang, Shi-Wen; Peng, Yun-Gui
Chirality, 2011 , vol. 23, # 10 p. 921 - 928
反应条件
1: iBuOCOCl, NEt3 3: silver benzoate View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 20 p. 3609 - 3610
反应条件
1: 88 percent / DMAP / tetrahydrofuran / 3 h / Heating 2: H2; (S,S)-1,3-dimethyl-4,5-(Ph2PCH2)2-imidazolidin-2-one / [Rh(cod)2]BF4 / CH2Cl2 / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 14 p. 2209 - 2212
反应条件
1: 88 percent / DMAP / tetrahydrofuran / 3 h / Heating 2: H2; (S,S)-1,3-dimethyl-4,5-(Ph2PCH2)2-imidazolidin-2-one / [Rh(cod)2]BF4 / CH2Cl2 / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 14 p. 2209 - 2212
反应条件
1: diazomethane; (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester in diethyl ether T=0°C; Condensation; 3 h; 2: methanol With silver benzoate; triethylamine T=0 - 20°C; Arndt-Eistert's reaction; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2621 - 2624
反应条件
1: diethyl ether / 16 h / 20 °C 2: 99 percent / PhCOOAg; Et3N / 3 h / -25 - 20 °C View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 24 p. 3623 - 3631
反应条件
2: silver benzoate View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 20 p. 3609 - 3610
反应条件
silver benzoate; chloroformic acid ethyl ester; triethylamine 1.) Et2O, -5 deg C, 5 min, 2.) Et2O, 5-20 deg C, 16 h, 3.) MeOH, RT, 10 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 13 p. 2369 - 2376
