(S)-2-羟基丁酸正丁酯合成路线 (共 5 条)
反应条件
copper(l) chloride in diethyl ether T=-78°C; 0.25 h; Product distribution / selectivity;
参考文献
Kowa Company, Ltd.
Patent: EP1908747 A1, 2008 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
in toluene T=30°C; 2.5 h; lipase from Candida cylindracea;
参考文献
Parida, Sanghamitra; Dordick, Jonathan S.
Journal of the American Chemical Society, 1991 , vol. 113, # 6 p. 2253 - 2259
反应条件
1: With copper(l) iodide in tetrahydrofuran; diethyl ether T=-78°C; 0.333333 h; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; diethyl ether; water Inert atmosphere; ConcentrationReagent/catalystTime;
参考文献
Araki, Takaaki; Koura, Minoru; Yamazaki, Yukiyoshi; Shibuya, Kimiyuki
Synthesis (Germany), 2013 , vol. 45, # 10 art. no. SS-2013-T0133-FA, p. 1319 - 1324
反应条件
Candida rugosa lipase in cyclohexane T=25°C; enantioselectivity, catalytic efficiency; other acids, other alcohols, other solvents, also transesterification reactions; Kinetics;
参考文献
Parida, Sanghamitra; Dordick, Jonathan S.
Journal of Organic Chemistry, 1993 , vol. 58, # 12 p. 3238 - 3244
反应条件
lithium (hydro)trimethoxyaluminate in diethyl ether T=4°C;
参考文献
Parida, Sanghamitra; Dordick, Jonathan S.
Journal of the American Chemical Society, 1991 , vol. 113, # 6 p. 2253 - 2259