4-羟基-6-甲基香豆素合成路线 （共 23 条）
反应条件
sodium hydride in mineral oil T=0 - 100°C;
参考文献
Nolan, Karen A.; Doncaster, Jeremy R.; Dunstan, Mark S.; Scott, Katherine A.; Frenkel, A. David; Siegel, David; Ross, David; Barnes, John; Levy, Colin; Leys, David; Whitehead, Roger C.; Stratford, Ian J.; Bryce, Richard A.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7142 - 7156
反应条件
triethylamine in tetrahydrofuran T=80°C; P=7355.08 Torr; 4 h;
参考文献
Mizuno, Takumi; Nishiguchi, Ikuzo; Hirashima, Tsuneaki; Ogawa, Akiya; Kambe, Nobuaki; Sonoda, Noboru
Synthesis, 1988 , # 3 p. 257 - 259
反应条件
phosphorous pentoxide in methanesulfonic acid T=70°C; 5 h;
参考文献
Bartlett, Mark J.; Turner, Claire A.; Harvey, Joanne E.
Organic Letters, 2013 , vol. 15, # 10 p. 2430 - 2433
反应条件
zinc(II) chloride; trichlorophosphate T=60 - 65°C; 12 h;
参考文献
Shen, Qiong; Shao, Jialiang; Peng, Quan; Zhang, Wanjin; Ma, Lin; Chan, Albert S. C.; Gu, Lianquan
Journal of Medicinal Chemistry, 2010 , vol. 53, # 23 p. 8252 - 8259
反应条件
1: 3 h / 100 °C / Neat (no solvent) 2: Eaton’s reagent / 4 h / 70 °C / Neat (no solvent) View Scheme
参考文献
Synthetic Communications, , vol. 40, # 5 p. 732 - 738
反应条件
potassium hydroxide in methanol Hydrolysis; 0.5 h; Heating;
参考文献
Sosnovskikh; Kutsenko; Ovsyannikov
Russian Chemical Bulletin, 2000 , vol. 49, # 3 p. 478 - 481
反应条件
1: 49 percent / PhN(Me)MgBr / diethyl ether / 3 h / 20 °C 2: 96 percent / conc. HCl / 24 h / 20 °C 3: 71 percent / KOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Chemical Bulletin, , vol. 49, # 3 p. 478 - 481
反应条件
1: 96 percent / conc. HCl / 24 h / 20 °C 2: 71 percent / KOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Chemical Bulletin, , vol. 49, # 3 p. 478 - 481
反应条件
hydrogenchloride; 3-chloro-benzenecarboperoxoic acid 1.) benzene, reflux, 3 h, 2.) reflux, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Synthetic Communications, , vol. 17, # 12 p. 1507 - 1512
反应条件
1: AlCl3, aluminium chloride / 120 °C 2: sodium hydride View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 65, p. 389 - 402
