1: 5-chloro-thiophene-2-carboxylic acid (S)-2-hydroxy-3-tosyloxy-propyl-amide With pyridine; acetic anhydride T=0°C; 1 h; 2: With hydrogenchloride in tert-butyl methyl ether; water pH=2; 3: [4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester With lithium tert-butylate in methanol; acetonitrile T=0°C; 17 h;

1: 2,3,4-trimethylpyridine / butan-1-ol; toluene; ethanol / 20 - 105 °C 2: toluene; 1-methyl-pyrrolidin-2-one / 3.5 h / 20 - 110 °C / Inert atmosphere View Scheme