4-(4-异氰酰苯基)吗啉-3-酮合成路线 （共 2 条）
反应条件
tris(n-butyl)phosphine oxide; lithium bromide in toluene 3 h; Inert atmosphereReflux;
参考文献
SANDOZ AG; STURM, Hubert; DE SOUZA, Dominic; KNEPPER, Kerstin; ALBERT, Martin
Patent: WO2011/98501 A1, 2011 ;
Location in patent: Page/Page column 29 ;
反应条件
1: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 3: 5 Pd(II)/C(eggshell); hydrogen / ethyl acetate / 12 h 4: triethylamine / dichloromethane / 1 h / 0 °C View Scheme
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MCCARTHY, James R.
Patent: WO2013/152168 A1, 2013 ;
