反应条件
1: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 18 h / Ambient temperature 2: LiOH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature 3: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 18 h / Ambient temperature 4: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Vacca; Guare; deSolms; Sanders; Giuliani; Young; Darke; Zugay; Sigal; Schleif; Quintero; Emini; Anderson; Huff
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1225 - 1228
