(2S,4R)-4-氨基吡咯烷-1,2-二甲酸 1-叔丁酯合成路线 （共 10 条）
反应条件
pyrrolidine in acetonitrile T=20°C; 3 h;
参考文献
US2008/107623 A1, ;
Page/Page column 75-76 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol; water P=3878.61 Torr; 28 h;
参考文献
Fisher, Abigail; Mann, Amandeep; Verma, Vaneeta; Thomas, Nancy; Mishra, Ram K.; Johnson, Rodney L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 307 - 317
反应条件
hydrogen; palladium on activated charcoal in ethanol; water P=5171.5 Torr;
参考文献
Webb, Thomas R.; Eigenbrot, Charles
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016
参考文献
Genentech, Inc.
Patent: US5120859 A1, 1992 ;
反应条件
1: 99 percent / NaN3 / dimethylformamide / 55 °C 2: 95 percent / H2 / Pd/C / ethanol; H2O / 28 h / 3878.61 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 1 p. 307 - 317
反应条件
1: 82 percent / CBr4; 1,2-bis(diphenylphosphino)ethane / tetrahydrofuran / 20 h / 20 °C 2: 99 percent / NaN3 / dimethylformamide / 55 °C 3: 95 percent / H2 / Pd/C / ethanol; H2O / 28 h / 3878.61 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 1 p. 307 - 317
反应条件
1: 80 percent / NaN3 / dimethylformamide / 64 h / 75 °C 2: 77 percent / 1M NaOH / methanol / 22 °C 3: 67 percent / H2 / 10percent Pd/C / ethanol; H2O / 5171.5 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 9 p. 3009 - 3016
反应条件
1: 77 percent / 1M NaOH / methanol / 22 °C 2: 67 percent / H2 / 10percent Pd/C / ethanol; H2O / 5171.5 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 9 p. 3009 - 3016
反应条件
1: 76 percent / PPh3, CCl4 / CH2Cl2 / 2 h 2: 80 percent / NaN3 / dimethylformamide / 64 h / 75 °C 3: 77 percent / 1M NaOH / methanol / 22 °C 4: 67 percent / H2 / 10percent Pd/C / ethanol; H2O / 5171.5 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 9 p. 3009 - 3016
反应条件
sodium carbonate in tetrahydrofuran T=20°C; 2 h;
参考文献
Zanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; Curti, Claudio; Sartori, Andrea; Nicastro, Giuseppe; Menchi, Gloria; Cini, Nicoletta; Bottonocetti, Anna; Raspanti, Silvia; Casiraghi, Giovanni
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1771 - 1782
