(2S,4s)-1-(叔丁氧基羰基)-4-氰基吡咯烷-2-羧酸合成路线 （共 9 条）
反应条件
water; lithium hydroxide hydrate T=40°C; 3 h;
参考文献
Alam, Muzaffar; Berthel, Steven Joseph; Brinkman, John A.; Hawley, Ronald Charles; Li, Hongju; Palmer, Wylie Solang; Pietranico-Cole, Sherrie; Sarabu, Ramakanth; Smith, Mark; So, Sung-Sau; Yi, Lin; Zhai, Yansheng; Zhang, Qiang; Zhao, Shu-Hai
Patent: US2012/230951 A1, 2012 ;
Location in patent: Page/Page column 104 ;
反应条件
sodium hydroxide in methanol T=22°C; 16 h;
参考文献
Webb, Thomas R.; Eigenbrot, Charles
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran 16 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; chloroform; water
参考文献
Akritopoulou-Zanze, Irini; Darczak, Daria; Dinges, Jurgen; Djuric, Stevan W.; Hoff, Ethan D.; Kopecka, Hana A.; Patel, Jyoti R.; Pei, Zhonghua; Shuai, Qi; Sarris, Kathy; Sham, Hing L.; Wiedeman, Paul E.
Patent: US2005/215603 A1, 2005 ;
Location in patent: Page/Page column 25; 39 ;
US 20050215603 A1
反应条件
1: 3.0 g / dimethylsulfoxide / 55 h / 55 °C 2: 76 percent / 1M NaOH / methanol / 16 h / 22 °C View Scheme
参考文献
Webb, Thomas R.; Eigenbrot, Charles
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016
反应条件
1.1: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere 2.1: sodium hydroxide; water / methanol / 20 °C 2.2: pH 2 View Scheme
参考文献
LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang
Patent: US2013/115194 A1, 2013 ;
反应条件
1.1: triethylamine / dichloromethane / 1.83 h / 0 - 20 °C 2.1: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere 3.1: sodium hydroxide; water / methanol / 20 °C 3.2: pH 2 View Scheme
参考文献
LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang
Patent: US2013/115194 A1, 2013 ;
反应条件
1.1: triethylamine / dichloromethane / 20 °C 2.1: triethylamine / dichloromethane / 1.83 h / 0 - 20 °C 3.1: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere 4.1: sodium hydroxide; water / methanol / 20 °C 4.2: pH 2 View Scheme
参考文献
LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang
Patent: US2013/115194 A1, 2013 ;
反应条件
1.1: triethylamine / dichloromethane / 20 °C 2.1: triethylamine / dichloromethane / 1.83 h / 0 - 20 °C 3.1: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere 4.1: sodium hydroxide; water / methanol / 20 °C 4.2: pH 2 View Scheme
参考文献
LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang
Patent: US2013/115194 A1, 2013 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol; water T=22°C; P=23271.7 Torr; 16 h;
参考文献
Journal of Organic Chemistry, , vol. 56, # 9 p. 3009 - 3016
