(2R,4S)-1-BOC-4-氨基-吡咯烷-2-羧酸合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol; water P=5171.5 Torr;
参考文献
Webb, Thomas R.; Eigenbrot, Charles
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016
参考文献
Genentech, Inc.
Patent: US5120859 A1, 1992 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 24 h;
参考文献
Zanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; Curti, Claudio; Sartori, Andrea; Nicastro, Giuseppe; Menchi, Gloria; Cini, Nicoletta; Bottonocetti, Anna; Raspanti, Silvia; Casiraghi, Giovanni
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1771 - 1782
反应条件
1: 72 percent / pyridine / 22 °C 2: 93 percent / NaN3 / dimethylformamide / 16 h / 55 °C 3: 51 percent / 1M NaOH / methanol / 22 °C 4: 97 percent / H2 / 10percent Pd/C / H2O; ethanol / 5171.5 Torr View Scheme
参考文献
Webb, Thomas R.; Eigenbrot, Charles
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016
反应条件
1: 51 percent / 1M NaOH / methanol / 22 °C 2: 97 percent / H2 / 10percent Pd/C / H2O; ethanol / 5171.5 Torr View Scheme
参考文献
Webb, Thomas R.; Eigenbrot, Charles
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016
