4-(2-Boc-氨基乙基)苯甲酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in water; tert-butyl alcohol T=20°C; 16 h; 2: With hydrogenchloride in water pH=2;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/158426 A1, 2009 ;
Location in patent: Page/Page column 105 ;
WO 2009/158426 A1
反应条件
sodium hydroxide in water T=20°C; 4 h;
参考文献
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; LUDWIG INSTITUTE FOR CANCER RESEARCH LIMITED; LESSENE, Guillaume Laurent; BAELL, Jonathan Bayldon; BURGESS, Antony Wilks; MARUTA, Hiroshi
Patent: WO2012/3544 A1, 2012 ;
Location in patent: Page/Page column 55 ;
WO 2012/003544 A1
反应条件
potassium hydroxide; acetic acid in ethanol; water
参考文献
LABORATORIOS MENARINI S.A.
Patent: EP775133 B1, 2001 ;
反应条件
1: N-(tert-butoxycarbonyl)-4-bromophenethylamine With n-butyllithium in diethyl ether; hexane T=0 - 20°C; 1.25 h; 2: carbon dioxide in diethyl ether; hexane T=-78 - 20°C; 1 h; Cooling with acetone-dry ice;
参考文献
US6339087 B1, ;
Page column 65 ;
US 6339087 B1
反应条件
n-butyllithium; carbon dioxide in hexane; water
反应条件
borane-THF in tetrahydrofuran
T=20°C; 1 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/158426 A1, 2009 ;
Location in patent: Page/Page column 105-106 ;
WO 2009/158426 A1
