1: (R)-3-Amino-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-methyl-propan-1-one; hydrochloride With lithium hydroxide; tetrabutylammomium bromide; lithium bromide in acetonitrile saponification; 3 h; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in ethanol T=20°C; Condensation; Further stages.;

lithium hydroxide in diethyl ether; water 20 h;

Yield given. Multistep reaction;

hydrogenchloride; dowex in 1,4-dioxane 4 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

hydrogenchloride; dowex in 1,4-dioxane 4 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;