5,5-二甲基-3-溴环己-2-烯酮合成路线 （共 11 条）
反应条件
(COBr)2; N,N-dimethyl-formamide in dichloromethane 0 deg C, 5 min, then to room temp., 30 min;
参考文献
Tetrahedron Letters, , vol. 30, # 29 p. 3753 - 3756
反应条件
BzNEt3Br; boron trifluoride diethyl etherate in dichloromethane 5 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 46, p. 197 - 201
反应条件
carbon tetrabromide; triphenylphosphine in chloroform
反应条件
1: KOH-solution 2: chloroform; phosphorus tribromoide View Scheme
参考文献
Journal of the Chemical Society, , vol. 83, p. 116,128
参考文献
Journal of the Chemical Society, , vol. 83, p. 116,128
反应条件
CuSPh in tetrahydrofuran; diethyl ether T=0°C; 2.5 h;
参考文献
Piers, Edward; Cheng, Kin Fai; Nagakura, Isao
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1256 - 1263
反应条件
1: 72 percent / p-toluenesulfonic acid monohydrate / benzene / 23 h / Heating 2: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h, 2.) a) -78 deg C, 1 h, b) RT, 1 h View Scheme
参考文献
Shih, Chuan; Swenton, John S.
Tetrahedron Letters, 1981 , vol. 22, # 42 p. 4217 - 4220
反应条件
in diethyl ether T=0°C; 1 h;
参考文献
Piers, Edward; Cheng, Kin Fai; Nagakura, Isao
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1256 - 1263
反应条件
palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
T=120°C; Buchwald-Hartwig Coupling; Microwave irradiationInert atmosphereSealed tube;
参考文献
Khader, K.K. Abdul; Sajith, Ayyiliath M.; Padusha, M. Syed Ali; Nagaswarupa; Muralidharan
New Journal of Chemistry, 2014 , vol. 38, # 3 p. 1294 - 1305
反应条件
1: 36.2 percent / NaOH / ethanol / Ambient temperature
2: lithium aluminum hydride / diethyl ether / 1) 0.5 h, r.t.; 2)1.5 h, reflux
3: trifluoroacetic acid / CCl4
View Scheme
参考文献
Matoba, Katsuhide; Tokizawa, Minoru; Morita, Takashi; Yamazaki, Takao
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 1 p. 368 - 372
