3,5-二甲基-2,2,2-三氟苯乙酮合成路线 (共 3 条)
反应条件
1: 1-bromo-3,5-dimethyl-benzene With n-butyllithium in diethyl ether T=-30 - 0°C; 2.5 h; 2: trifluoro acetic acid methyl ester in diethyl ether T=-50°C; 3 h; Further stages.;
参考文献
Halbfinger, Efrat; Gorochesky, Karine; Levesque, Sebastien A.; Beaudoin, Adrien R.; Sheihet, Larisa; Margel, Shlomo; Fischer, Bilha
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 16 p. 2821 - 2832
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.5 h; Inert atmosphere;
参考文献
Hyster, Todd K.; Ruhl, Kyle E.; Rovis, Tomislav
Journal of the American Chemical Society, 2013 , vol. 135, # 14 p. 5364 - 5367
参考文献
Murata; Goto; Fujiyama; Mishima; Fujio; Tsuno
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1129 - 1137