[(2S,4S,5R)-4-氟-5-嘌呤-9-基四氢呋喃-2-基]甲醇合成路线 （共 6 条）
反应条件
acetic acid T=90°C; 0.583333 h;
参考文献
Barchi, Joseph J.; Marquez, Victor E.; Driscoll, John S.; Ford, Harry; Mitsuya, Hiroaki; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1647 - 1655
反应条件
1: 76 percent / H2SO4 / H2O; dioxane / 4 h / 70 - 80 °C 2: 49.8 percent / (diethylamino)sulfur trifluoride / CH2Cl2 / 0 - 25 °C 3: 20 percent / TMSOTf / 1,2-dichloro-ethane / Heating 4: H2, NH4OH / 10percent Pd/C / methanol; tetrahydrofuran / 3 h / 2585.7 Torr / Ambient temperature 5: methanolic ammonia View Scheme
参考文献
Shanmuganathan, Kirupa; Koudriakova, Tatiana; Nampalli, Satyanarayana; Du, Jinfa; Gallo, James M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 821 - 827
反应条件
1: 20 percent / TMSOTf / 1,2-dichloro-ethane / Heating 2: H2, NH4OH / 10percent Pd/C / methanol; tetrahydrofuran / 3 h / 2585.7 Torr / Ambient temperature 3: methanolic ammonia View Scheme
参考文献
Shanmuganathan, Kirupa; Koudriakova, Tatiana; Nampalli, Satyanarayana; Du, Jinfa; Gallo, James M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 821 - 827
反应条件
1: 20 percent / TMSOTf / 1,2-dichloro-ethane / Heating 2: H2, NH4OH / 10percent Pd/C / methanol; tetrahydrofuran / 3 h / 2585.7 Torr / Ambient temperature 3: methanolic ammonia View Scheme
参考文献
Shanmuganathan, Kirupa; Koudriakova, Tatiana; Nampalli, Satyanarayana; Du, Jinfa; Gallo, James M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 821 - 827
反应条件
1: H2, NH4OH / 10percent Pd/C / methanol; tetrahydrofuran / 3 h / 2585.7 Torr / Ambient temperature 2: methanolic ammonia View Scheme
参考文献
Shanmuganathan, Kirupa; Koudriakova, Tatiana; Nampalli, Satyanarayana; Du, Jinfa; Gallo, James M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 821 - 827
反应条件
1: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 0 deg C, 30 min 2: 65 percent / AIBN, tri-n-butyltin hydride / toluene / 0.17 h / 90 °C 3: 88 percent / 80percent acetic acid / 0.58 h / 90 °C View Scheme
参考文献
Barchi, Joseph J.; Marquez, Victor E.; Driscoll, John S.; Ford, Harry; Mitsuya, Hiroaki; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1647 - 1655
