4-氯-2,5-二氟苯甲酸合成路线 （共 6 条）
反应条件
hydrogenchloride; potassium hydroxide in water
反应条件
hydrogenchloride in sodium hypobromide; water
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / 80 °C 2: ammonium hydroxide / chloroform / 5 °C 3: trichlorophosphate / 80 °C View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
sulfuric acid
18 h; Heating / reflux;
参考文献
Pfizer Inc
Patent: US2007/21634 A1, 2007 ;
Location in patent: Page/Page column 4; 6 ;
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / 80 °C
2: ammonium hydroxide / chloroform / 5 °C
View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
