1: With potassium carbonate in dichloromethane; water 2: With hydrogenchloride in dichloromethane; water

1: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethyl ethyl ester hydrochloride With triethylamine in propan-1-ol; dichloromethane T=25 - 30°C; pH=~ 8 - ~ 9; 2: 3-amino-2-butenoic acid,methyl ester in propan-1-ol; dichloromethane T=75 - 80°C; 10 h; 3: With hydrogenchloride in propan-1-ol T=20 - 30°C; pH=~ 3 - ~ 4; 0.5 h;

1: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethyl ethyl ester hydrochloride With triethylamine in propan-1-ol T=25 - 40°C; 0.166667 h; 2: methyl 3-aminocrotonate in propan-1-ol T=75 - 80°C; 10 h; 3: With hydrogenchloride in propan-1-ol T=25 - 30°C; pH=2; 0.5 h;

hydrogenchloride in diethyl ether; tert-butyl methyl ether Product distribution / selectivity;

1: in xylene 10 h; Heating / refluxBasic conditions; 2: With hydrogenchloride in diethyl ether; xylene 24 h;

in dichloromethane T=-10 - 30°C;

1: in toluene 4 h; Heating / reflux; 2: With hydrogenchloride in water; ethyl acetate Product distribution / selectivity;

sodium methylate in methanol T=20 - 25°C; 4.5 h; Product distribution / selectivity;