(R)-1-苄基-3-甲基哌嗪合成路线 （共 12 条）
反应条件
potassium carbonate in ethanol Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/2577 A1, 2005 ;
Location in patent: Page 290-291 ;
WO 2005/002577 A1
反应条件
potassium carbonate in ethanol T=0 - 60°C; 8 h;
参考文献
WO2009/75857 A2, ;
Page/Page column 78-79 ;
WO 2009/075857 A2
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 36 h;
参考文献
Liu, Bo; Xu, Guang-Yu; Yang, Chun-Hao; Wu, Xi-Han; Xie, Yu-Yuan
Synthetic Communications, 2004 , vol. 34, # 22 p. 4111 - 4118
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 16 h; Heating; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 60, # 13 p. 4177 - 4183
反应条件
1: DEAD, PPh3 / tetrahydrofuran / 16 h / Ambient temperature 2: LAH / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 13 p. 4177 - 4183
反应条件
1: TFA / CH2Cl2 / 1.75 h / 0 °C 2: DEAD, PPh3 / tetrahydrofuran / 16 h / Ambient temperature 3: LAH / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 13 p. 4177 - 4183
反应条件
1: 1).CDI / 1.) THF, room temp., 1 h, 2.) THF, room temp., 16 h 2: TFA / CH2Cl2 / 1.75 h / 0 °C 3: DEAD, PPh3 / tetrahydrofuran / 16 h / Ambient temperature 4: LAH / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 13 p. 4177 - 4183
反应条件
1: 78 percent / triethylamine / methanol / 20 h / Heating 2: 81 percent / lithium aluminum hydride / tetrahydrofuran / 36 h / 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 34, # 22 p. 4111 - 4118
反应条件
in dichloromethane T=23°C; 48 h; aminomethyl polystyrene resin; Inert atmosphereResolution of racemate;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 42 p. 10660 - 10663
Angew. Chem., , vol. 124, # 42 p. 10815 - 10819,5
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol T=20°C; P=760 Torr; 24 h;
参考文献
Liu, Bo; Xu, Guang-Yu; Yang, Chun-Hao; Wu, Xi-Han; Xie, Yu-Yuan
Synthetic Communications, 2004 , vol. 34, # 22 p. 4111 - 4118
