苯基4-甲基-1-哌嗪羧酸酯合成路线 （共 3 条）
反应条件
1: 41 percent / N2H4*H2O / 12 h / 80 - 90 °C 2: 60 percent / p-TsOH / toluene / 10 h / Ambient temperature View Scheme
参考文献
Cerecetto, Hugo; Di Maio, Rossanna; Ibarruri, Gerardo; Seoane, Gustavo; Denicola, Ana; Peluffo, Gonzalo; Quijano, Celia; Paulino, Margot
Farmaco, 1998 , vol. 53, # 2 p. 89 - 94
反应条件
hydrazine hydrate
T=80 - 90°C; 12 h;
参考文献
Cerecetto, Hugo; Di Maio, Rossanna; Ibarruri, Gerardo; Seoane, Gustavo; Denicola, Ana; Peluffo, Gonzalo; Quijano, Celia; Paulino, Margot
Farmaco, 1998 , vol. 53, # 2 p. 89 - 94
反应条件
Multi-step reaction with 2 steps 1: 88.6 percent / Et3N / CH2Cl2 / 1.67 h / 5 °C2: 49.3 percent / benzene / a.) RT, 1 h, b.) reflux, 1 h
参考文献
Patonay, Tamas; Patonay-Peli, Erzsebet; Mogyorodi, Ferenc Synthetic Communications, 1990 , vol. 20, # 18 p. 2865 - 2885
