1-二苯甲基-3-(3,4-二氯-苯氧基)氮杂丁烷合成路线 （共 3 条）
反应条件
1: 3,4-dichloro-phenol With sodium hydride in DMF (N,N-dimethyl-formamide) 0.166667 h; 2: 1-benzhydryl-3-methanesulfonyloxyazetidine in DMF (N,N-dimethyl-formamide) T=60°C; 20 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/26113 A1, 2005 ;
Location in patent: Page 52-53 ;
WO 2005/026113 A1
反应条件
sodium hydroxide; tetrabutylammomium bromide; triethylamine in water; methanesulfonyl chloride; toluene
参考文献
A. H. Robins Company Incorporated
Patent: US5068231 A1, 1991 ;
反应条件
potassium carbonate in ligroin; dichloromethane
参考文献
A. H. Robins Company Incorporated
Patent: US5068231 A1, 1991 ;
