2-甲氧基-4-(三氟甲氧)苯甲醛合成路线 （共 8 条）
反应条件
methanol T=50°C; 6 h;
参考文献
WO2009/158426 A1, ;
Page/Page column 69 ;
WO 2009/158426 A1
反应条件
1: 1-trifluoromethyl-3-methoxybenzene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine; diisopropylamine in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide T=-78°C; 0.5 h; Inert atmosphere; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 54, # 45 p. 6053 - 6056
反应条件
hydrogenchloride; diisobutylaluminium hydride in water; toluene
反应条件
in water; N,N-dimethyl-formamide
参考文献
EP1216980 A1, ;
EP 1216980 A1
反应条件
manganese(IV) oxide in dichloromethane T=20°C; Oxidation; 1.3 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 5 p. 694 - 707
反应条件
1: DIBAL / toluene / 1 h / 0 °C 2: MnO2 / CH2Cl2 / 1.3 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 5 p. 694 - 707
反应条件
sodium in water; dimethyl sulfoxide
参考文献
Eisai Co., Ltd.
Patent: EP1216980 A1, 2002 ;
EP 1216980 A1
反应条件
lithium chloride in N-methyl-acetamide; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/5909 A1, 2006 ;
Location in patent: Page/Page column 31 ;
WO 2006/005909 A1
