1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 2: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme

1.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 2.1: zinc / dichloromethane / 0 - 20 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 4.1: hydrogenchloride / tetrahydrofuran; water / 20 °C 4.3: 0.17 h View Scheme

1.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 2.1: zinc / dichloromethane / 0 - 20 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 4.1: hydrogenchloride / tetrahydrofuran; water / 20 °C 4.3: 0.17 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '10512883', constants.ctx, '0')">Grubb's 2nd generation catalyst</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=50&deg;C;&nbsp;6&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: N,N-dimethyl-formamide / 36 h / 50 &deg;C<br />2: triethylamine / dichloromethane / 3 h / Inert atmosphere<br />3: toluene-4-sulfonic acid / tetrahydrofuran; water / 20 &deg;C<br />4: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 &deg;C / Inert atmosphere<br /> <br /> &nbsp;