potassium tert-butylate in tetrahydrofuran T=0 - 20°C; Inert atmosphere;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587194', constants.ctx, '0')">iodine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '610776', constants.ctx, '0')">triphenylphosphine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br />T=0&deg;C;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: N,N-dimethyl-formamide / 36 h / 50 &deg;C<br />2: triethylamine / dichloromethane / 3 h / Inert atmosphere<br />3: toluene-4-sulfonic acid / tetrahydrofuran; water / 20 &deg;C<br />4: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 &deg;C / Inert atmosphere<br />5: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h<br />6: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 &deg;C / Inert atmosphere<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 &deg;C / Inert atmosphere<br />2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h<br />3: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 &deg;C / Inert atmosphere<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h<br />2: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 &deg;C / Inert atmosphere<br /> <br /> &nbsp;