in water; dimethyl sulfoxide; ethyl acetate

1: (S)-3-Cyano-pyrrolidine-1-carboxylic acid tert-butyl ester With hydrogenchloride; water T=100°C; 3 h; 2: methanol With chloro-trimethyl-silane T=0 - 20°C; 16 h; 3: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine T=0 - 20°C; 16 h;

1: With lithium aluminium tetrahydride in diethyl ether T=0°C; 2: With sodium hydroxide in diethyl ether