4-[4-(4-O-甲氧基甲基-4-羟基苯基)-1-哌嗪基]苯基]氨基甲酸苯基酯合成路线 （共 5 条）
反应条件
pyridine in acetonitrile T=0 - 20°C; Inert atmosphere;
参考文献
THE JOHNS HOPKINS UNIVERSITY; LIU, Jun, O.; SHI, Wei; PASUNOOTI, Kalyan, Kumar
Patent: WO2013/36866 A1, 2013 ;
Location in patent: Paragraph 0237 ;
反应条件
1: palladium 10 on activated carbon; hydrazine hydrate / ethanol / 3.5 h / Reflux; Inert atmosphere 2: pyridine / acetonitrile / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
THE JOHNS HOPKINS UNIVERSITY; LIU, Jun, O.; SHI, Wei; PASUNOOTI, Kalyan, Kumar
Patent: WO2013/36866 A1, 2013 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrazine hydrate / ethanol / 3.5 h / Reflux; Inert atmosphere 3: pyridine / acetonitrile / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
THE JOHNS HOPKINS UNIVERSITY; LIU, Jun, O.; SHI, Wei; PASUNOOTI, Kalyan, Kumar
Patent: WO2013/36866 A1, 2013 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 125 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrazine hydrate / ethanol / 3.5 h / Reflux; Inert atmosphere 4: pyridine / acetonitrile / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Shi, Wei; Nacev, Benjamin A.; Aftab, Blake T.; Head, Sarah; Rudin, Charles M.; Liu, Jun O.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 20 p. 7363 - 7374
反应条件
1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 125 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrazine hydrate / ethanol / 3.5 h / Reflux; Inert atmosphere 4: pyridine / acetonitrile / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Shi, Wei; Nacev, Benjamin A.; Aftab, Blake T.; Head, Sarah; Rudin, Charles M.; Liu, Jun O.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 20 p. 7363 - 7374
