4-(吡啶-4-基)苯胺合成路线 （共 20 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHONBRUNN, Ernst; LI, Rongshi; SEBTI, Said M.
Patent: WO2013/112722 A1, 2013 ;
Location in patent: Page/Page column 45 ;
反应条件
hydrogenchloride in methanol 1 h; Inert atmosphereReflux;
参考文献
Conole, Daniel; Beck, Thorsten M.; Jay-Smith, Morgan; Tingle, Malcolm D.; Eason, Charles T.; Brimble, Margaret A.; Rennison, David
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2220 - 2235
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
参考文献
Agouron Pharmaceuticals, Inc.
Patent: EP1215208 A2, 2002 ;
Location in patent: Example C(122) ;
EP 1215208 A2
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; N,N-dimethyl-formamide 24 h; Heating;
参考文献
Vella, Sarah J.; Tiburcio, Jorge; Loeb, Stephen J.
Chemical Communications, 2007 , # 45 p. 4752 - 4754
反应条件
potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 3 h; Heating;
参考文献
Ishikura; Ohta; Terashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4755 - 4763
反应条件
potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 12 h; Heating;
参考文献
Ishikura; Ohta; Terashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4755 - 4763
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water; N,N-dimethyl-formamide Reflux;
参考文献
Gunderson, Victoria L.; Smeigh, Amanda L.; Kim, Chul Hoon; Co, Dick T.; Wasielewski, Michael R.
Journal of the American Chemical Society, 2012 , vol. 134, # 9 p. 4363 - 4372
反应条件
1: 61 percent / t-BuOK, Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 8 h / 84 °C 2: 57 percent / 1M aq. HCl / methanol / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 22 p. 3542 - 3550
反应条件
1: 61 percent / t-BuOK, Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 8 h / 84 °C 2: 57 percent / 1M aq. HCl / methanol / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 22 p. 3542 - 3550
反应条件
1: 100 percent / toluene / 15 h / 70 °C 2: 61 percent / t-BuOK, Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 8 h / 84 °C 3: 57 percent / 1M aq. HCl / methanol / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 22 p. 3542 - 3550
