4-(吡啶-4-基)苯胺合成路线 （共 20 条）
反应条件
1: 1.) NaNO2, HCl / 2.) 40 deg C, 3 h 2: 89 percent / 95percent hydrazine hydrate / 5percent Pd/C / ethanol / 1.5 h / Heating View Scheme
参考文献
Molecular crystals and liquid crystals, , vol. 62, # 1-2 p. 103 - 114
反应条件
1: 1.) NaNO2, HCl / 2.) 40 deg C, 3 h 2: 89 percent / 95percent hydrazine hydrate / 5percent Pd/C / ethanol / 1.5 h / Heating View Scheme
参考文献
Molecular crystals and liquid crystals, , vol. 62, # 1-2 p. 103 - 114
反应条件
1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 20 h / 100 °C 2: hydrogen; palladium 10 on activated carbon / methanol / 20 h View Scheme
反应条件
1.1: sodium hydrogencarbonate / water; ethanol; toluene / 0.25 h / |Inert atmosphere 1.2: 1 h / 120 °C / |Microwave irradiation; |Inert atmosphere 2.1: hydrogenchloride / methanol / 1 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 7 p. 2220 - 2235
反应条件
hydrogenchloride; sodium nitrite 1) 0 deg, C, 2) 100 deg C, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Didenko, S. I.; Akimenko, L. V.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 7 p. 1415 - 1416
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 7 p. 1573 - 1574
反应条件
hydrogenchloride; sodium nitrite 1) 0 deg, C, 2) 100 deg C, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 23, # 7 p. 1415 - 1416
Zhurnal Organicheskoi Khimii, , vol. 23, # 7 p. 1573 - 1574
反应条件
sulfuric acid; sodium nitrite in ammonium hydroxide; water
参考文献
Sterling Drug Inc.
Patent: US4310531 A1, 1982 ;
反应条件
sulfuric acid; sodium nitrite
1.) r.t., overnight, 2.) heating (steam bath), 4 h; Yield given. Multistep reaction;
参考文献
Byron; Lacey; Wilson
Molecular crystals and liquid crystals, 1980 , vol. 62, # 1-2 p. 103 - 114
反应条件
1: With tetrafluoroboric acid; sodium nitrite
T=-10°C; 0.5 h;
2: With potassium iodide in acetone
参考文献
Khlobystov, Andrei N.; Brett, Matthew T.; Blake, Alexander J.; Champness, Neil R.; Gill, Peter M. W.; O'Neill, Darragh P.; Teat, Simon J.; Wilson, Claire; Schroeder, Martin
Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6753 - 6761
反应条件
2: nitrosyl chloride; acetic acid anhydride; phosphorus (V)-oxide / weitere Reagentien Essigsaeure,Kaliumacetat;und Behandeln des Reaktionsprodukts mit Benzol
View Scheme
参考文献
Heilbron et al.
Journal of the Chemical Society, 1940 , p. 1279,1283
