1: O,N-dimethyl-hydroxylamine hydrochloride With pyridine in dichloromethane T=0°C; 0.25 h; 2: 2-methyl-acryloyl chloride in dichloromethane T=0 - 20°C;

pyridine in tetrahydrofuran

in tetrahydrofuran T=22°C;

AD-mix-β; methanesulfonamide; water; tert-butyl alcohol T=0 - 20°C; 26.0833 h;

methanesulfonamide; Modified-AD-mix-βTM in water; tert-butyl alcohol T=0°C; Yield given;

1: Weinreb amide of 2-methyl-2-propeonic acid With K2OsO2(OH)4; methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium carbonate; potassium hexacyanoferrate(III) in water; tert-butyl alcohol T=0 - 20°C; Sharpless asymmetric dihydroxylation; 2: With lithium hydroxide in methanol; water T=20°C; 5 h; 3: methanol With acetyl chloride Heating; Title compound not separated from byproducts;