吲哚-3-丁酸(IBA)-BBI合成路线 （共 31 条）
反应条件
PPA in toluene 5 h; Heating;
参考文献
Maingot, Lucie; Thuaud, Frederic; Sissouma, Drissa; Collet, Sylvain; Guingant, Andre; Evain, Michel
Synlett, 2008 , # 2 p. 263 - 267
反应条件
1: 52 percent / DBU / acetonitrile / 8 h / Heating 2: 90 percent / hydrazine monohydrate / ethanol / Heating View Scheme
参考文献
Rapolu, Sreevani; Alla, Manjula; Bommena, Vittal Rao; Murthy, Ramalinga; Jain, Nishant; Bommareddy, Venkata Ramya; Bommineni, Madhava Reddy
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 91 - 100
反应条件
Behandeln des Natrium-Salzes in wss. Loesung vom pH 7.2;
参考文献
Webley et al.
J. gen. Microbiol., 1958 , vol. 18, p. 733,743
反应条件
1: methanol. H2SO4 2: ethanol; aqueous N2H4 / 150 °C 3: NaNO2; aqueous acetic acid / Erwaermen des Reaktionsprodukts mit H2O 5: N2H4; aqueous ethanol View Scheme
参考文献
Jackson; Manske
Journal of the American Chemical Society, 1930 , vol. 52, p. 5029,5031
反应条件
1: methanol. H2SO4 2: ethanol; aqueous N2H4 / 150 °C 3: NaNO2; aqueous acetic acid / Erwaermen des Reaktionsprodukts mit H2O View Scheme
参考文献
Journal of the American Chemical Society, , vol. 52, p. 5029,5031
反应条件
hydrogenchloride; dimethyl sulfoxide 0.25 h;
参考文献
Thompson; Rewcastle; Tercel; Dobrusin; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2459 - 2469
反应条件
1: 85 percent / PPA / toluene / 4 h / 110 °C
2: 82 percent / KOH / acetone / 2 h / 20 °C
View Scheme
参考文献
Tunbridge, Gemma A.; Oram, Joseph; Caggiano, Lorenzo
MedChemComm, 2013 , vol. 4, # 11 p. 1452 - 1456
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 °C
1.2: 96 percent / NH3(g) / tetrahydrofuran / 2.5 h / 20 °C
2.1: 75 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Zelesko, Michael J.; McComsey, David F.; Hageman, William E.; Nortey, Samuel O.; Baker, Carol A.; Maryanoff, Bruce E.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 230 - 237
反应条件
sulfuric acid in water
T=0°C; Reflux;
参考文献
Pedras, M. Soledade C.; Minic, Zoran; Thongbam, Premila D.; Bhaskar, Vangala; Montaut, Sabine
Phytochemistry, 2010 , vol. 71, # 17-18 p. 1952 - 1962
参考文献
Kornet; Thio; Thorstenson
Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 7 p. 1022 - 1024
