3,6-二溴吡嗪-2-甲酸甲酯合成路线 （共 4 条）
反应条件
1: With hydrogen bromide; bromine; acetic acid in water T=0°C; 0.75 h; 2: With sodium nitrite in water T=0°C; 0.5 h; Product distribution / selectivity;
参考文献
de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael
Patent: US2011/59118 A1, 2011 ;
Location in patent: Page/Page column 84-85 ;
反应条件
1.1: bromine; acetic acid / water / 1 h / 25 - 45 °C 2.1: bromine; hydrogen bromide; acetic acid / water / 0.75 h / 0 °C 2.2: 0.5 h / 0 °C View Scheme
反应条件
1: sulfuric acid 2: bromine; acetic acid 3: hydrogen bromide; sodium nitrite / water View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 6 p. 2266 - 2270
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=0°C; 0.75 h; 2: With hydrogenchloride in dichloromethane; water
参考文献
de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael
Patent: US2011/59118 A1, 2011 ;
Location in patent: Page/Page column 57 ;
