4-甲基-2-苯基-2-噁唑啉-5-酮合成路线 （共 9 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane
参考文献
Weber, Manuel; Jautze, Sascha; Frey, Wolfgang; Peters, Rene
Journal of the American Chemical Society, 2010 , vol. 132, # 35 p. 12222 - 12225
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C;
参考文献
Dong, Shunxi; Liu, Xiaohua; Zhang, Yulong; Lin, Lili; Feng, Xiaoming
Organic Letters, 2011 , vol. 13, # 19 p. 5060 - 5063
反应条件
1: ClCOOEt; H3C-NC5H10 / CHCl3 View Scheme
参考文献
Sain, B.; Sandhu, J. S.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1007 - 1010
反应条件
1: sodium hydroxide / water; acetone / 20 °C 2: N,N-diethylaniline hydrochloride; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride / dichloromethane; water; acetone / 2 h / 20 °C View Scheme
参考文献
Fujita, Hikaru; Kunishima, Munetaka
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 7 p. 907 - 912
反应条件
1: 4-methyl-morpholine / water; acetone / 0.25 h / 20 °C 2: sodium hydroxide / water; acetone / 20 °C 3: N,N-diethylaniline hydrochloride; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride / dichloromethane; water; acetone / 2 h / 20 °C View Scheme
参考文献
Fujita, Hikaru; Kunishima, Munetaka
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 7 p. 907 - 912
反应条件
in benzene 5 h; Irradiation;
参考文献
Padwa, Albert; Akiba, Mitsuo; Cohen, Leslie A.; MacDonald, Gavin J.
Journal of Organic Chemistry, 1983 , vol. 48, # 5 p. 695 - 703
反应条件
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C;
参考文献
Dong, Shunxi; Liu, Xiaohua; Zhang, Yulong; Lin, Lili; Feng, Xiaoming Organic Letters, 2011 , vol. 13, # 19 p. 5060 - 5063
反应条件
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 20 °C2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
参考文献
Hsu, Mei-Yuan; Dietrich, Justin; Hulme, Christopher; Shaw, Arthur Y. Synthetic Communications, 2013 , vol. 43, # 11 p. 1538 - 1542
反应条件
Multi-step reaction with 5 steps 1.1: triethylamine / tetrahydrofuran / 1.17 h / 0 °C2.1: Birman's catalyst / chloroform-d1 / 48 h / 20 °C3.1: 4-(N,N-dimethlyamino)pyridine / 16 h4.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 20 °C4.2: 20 h / Cooling with ice5.1: thionyl chloride / tetrahydrofuran / 0 - 60 °C
参考文献
Dietz, Friedrich R.; Groeger, Harald Synthesis, 2009 , # 24 art. no. T08709SS, p. 4208 - 4218
