苯基甲基N-[(2S)-1-[[(2S,5S)-3,3-二氟-5-[[(2S)-3-甲基-2-(苯基甲氧羰基氨基)丁酰基]氨基]-4-氧代-1,6-二(苯基)己烷-2-基]氨基]-3-甲基-1-氧代丁烷-2-基]氨基甲酸酯合成路线 (共 5 条)
反应条件
1: 88 percent / tetrahydrofuran / 0 °C 2: hydroxylamine hydrochloride, pyridine 3: H2 / Raney nickel / ethanol 4: 95 percent / Ba(OH)2, H2O / dioxane 5: dicyclohexylcarbodiimide / dimethylformamide 6: Na2Cr2O7, AcOH View Scheme
参考文献
Sham, Hing L.; Wideburg, Norman E.; Spanton, Stephen G.; Kohlbrenner, William E.; Betebenner, David A.; et al.
Journal of the Chemical Society, Chemical Communications, 1991 , # 2 p. 110 - 112
反应条件
1: hydroxylamine hydrochloride, pyridine 2: H2 / Raney nickel / ethanol 3: 95 percent / Ba(OH)2, H2O / dioxane 4: dicyclohexylcarbodiimide / dimethylformamide 5: Na2Cr2O7, AcOH View Scheme
参考文献
Sham, Hing L.; Wideburg, Norman E.; Spanton, Stephen G.; Kohlbrenner, William E.; Betebenner, David A.; et al.
Journal of the Chemical Society, Chemical Communications, 1991 , # 2 p. 110 - 112
反应条件
1: 88 percent / tetrahydrofuran / 0 °C 2: hydroxylamine hydrochloride, pyridine 3: H2 / Raney nickel / ethanol 4: 95 percent / Ba(OH)2, H2O / dioxane 5: dicyclohexylcarbodiimide / dimethylformamide 6: Na2Cr2O7, AcOH View Scheme
参考文献
Sham, Hing L.; Wideburg, Norman E.; Spanton, Stephen G.; Kohlbrenner, William E.; Betebenner, David A.; et al.
Journal of the Chemical Society, Chemical Communications, 1991 , # 2 p. 110 - 112
反应条件
1: dicyclohexylcarbodiimide / dimethylformamide 2: Na2Cr2O7, AcOH View Scheme
参考文献
Sham, Hing L.; Wideburg, Norman E.; Spanton, Stephen G.; Kohlbrenner, William E.; Betebenner, David A.; et al.
Journal of the Chemical Society, Chemical Communications, 1991 , # 2 p. 110 - 112
反应条件
sodium dichromate; acetic acid
参考文献
Sham, Hing L.; Wideburg, Norman E.; Spanton, Stephen G.; Kohlbrenner, William E.; Betebenner, David A.; et al.
Journal of the Chemical Society, Chemical Communications, 1991 , # 2 p. 110 - 112