4-[(2-丁基-5-甲酰基-1H-咪唑-1-基)甲基]苯甲酸甲酯合成路线 （共 24 条）
反应条件
in methanol; potassium acetate
参考文献
US5308853 A1, ;
US 5308853 A
反应条件
1: 99 percent / K2CO3 / dimethylformamide / 19 h 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, 30 min 3: 98 percent / conc. HCl / aq. ethanol / 1.25 h / Heating 4: 91 percent / K2CO3 / dimethylformamide / 17 h / 80 °C 5: 96 percent / H2, NaOAc / 10percent Pd/C / methanol / 18 h View Scheme
参考文献
Synthetic Communications, , vol. 23, # 22 p. 3231 - 3248
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, 30 min 2: 98 percent / conc. HCl / aq. ethanol / 1.25 h / Heating 3: 91 percent / K2CO3 / dimethylformamide / 17 h / 80 °C 4: 96 percent / H2, NaOAc / 10percent Pd/C / methanol / 18 h View Scheme
参考文献
Synthetic Communications, , vol. 23, # 22 p. 3231 - 3248
反应条件
1: 91 percent / K2CO3 / dimethylformamide / 17 h / 80 °C 2: 96 percent / H2, NaOAc / 10percent Pd/C / methanol / 18 h View Scheme
参考文献
Synthetic Communications, , vol. 23, # 22 p. 3231 - 3248
反应条件
1: 98 percent / conc. HCl / aq. ethanol / 1.25 h / Heating 2: 91 percent / K2CO3 / dimethylformamide / 17 h / 80 °C 3: 96 percent / H2, NaOAc / 10percent Pd/C / methanol / 18 h View Scheme
参考文献
Synthetic Communications, , vol. 23, # 22 p. 3231 - 3248
反应条件
1: 93 percent / triethylamine / dimethylformamide / 16 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
1: 93 percent / triethylamine / dimethylformamide / 16 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
piperidine; propionic acid in cyclohexane T=25 - 35°C; 17 h; Heating / reflux;
参考文献
MATRIX LABORATORIES LIMITED; LAHIRI, Saswata; KOILKONDA, Purandhar; ACHANTA, Nageswara, Rao; RAPOLU, Sreedhar; ACHAR, Mouneshwar; LANDE, Hemaraj; SHARMA, Jitendra; DACHAPALLI, Venkanna; DATTA, Debashish
Patent: WO2010/23688 A2, 2010 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: With piperidine; hydrogenchloride in di-isopropyl ether; water T=40 - 55°C; P=760.051 Torr; Heating / reflux; 2: With water; sodium hydroxide in methanol 3 h; Heating / reflux; 3: With hydrogenchloride in methanol; water T=35 - 40°C; pH=5.0 - 5.2;
参考文献
NEULAND LABORATORIES LTD
Patent: WO2009/84028 A2, 2009 ;
Location in patent: Page/Page column 7; 11-12 ;
