4-[(2-丁基-5-甲酰基-1H-咪唑-1-基)甲基]苯甲酸甲酯合成路线 （共 24 条）
反应条件
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, 30 min 2: DMAP / CH2Cl2 / 2 h / Ambient temperature 3: DBU / toluene / 3 h / 80 °C 4: 58 percent / 3.75 M aq. NaOH / aq. ethanol / 4 h View Scheme
参考文献
Keenan, Richard M.; Weinstock, Joseph; Finkelstein, Joseph A.; Franz, Robert G.; Gaitanopoulos, Dimitri E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 13 p. 1880 - 1892
反应条件
piperidine; pyridine in toluene
参考文献
Weinstock, Joseph; Keenan, Richard M.; Samanen, James; Hempel, Judith; Finkelstein, Joseph A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1514 - 1517
反应条件
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, 30 min 2: DMAP / CH2Cl2 / 2 h / Ambient temperature 3: DBU / toluene / 3 h / 80 °C View Scheme
参考文献
Keenan, Richard M.; Weinstock, Joseph; Finkelstein, Joseph A.; Franz, Robert G.; Gaitanopoulos, Dimitri E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 13 p. 1880 - 1892
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Warner-Lambert Company
Patent: US5308853 A1, 1994 ;
US 5308853 A
