2-三氟甲基-4-羧酸乙酯噻唑合成路线 （共 8 条）
反应条件
Lawesson's reagent in tetrahydrofuran Reflux;
参考文献
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique
Patent: WO2011/17389 A1, 2011 ;
Location in patent: Page/Page column 161-162 ;
WO 2011/017389 A1
反应条件
1: trifluoromethyl amino ketone With Lawesson's reagent in tetrahydrofuran 18 h; Heating / reflux; 2: 3-bromo-2-oxopropionic acid ethyl ester in tetrahydrofuran 18 h; Heating / reflux;
参考文献
MERCK SHARP and DOHME LIMITED; NEUROGEN CORPORATION
Patent: WO2006/122200 A1, 2006 ;
Location in patent: Page/Page column 43-44 ;
WO 2006/122200 A1
参考文献
Kornacker, Michael G.; Mapelli, Claudio; Riexinger, Douglas James
Patent: US2013/289238 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
in tetrahydrofuran 18 h; Heating / reflux;
参考文献
WO2006/120481 A2, ;
Page/Page column 19 ;
WO 2006/120481 A2
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 1 h; 2: in tetrahydrofuran; methanol pH=1.5; Acidic conditions;
参考文献
ORION CORPORATION; WOHLFAHRT, Gerd; TOeRMAeKANGAS, Olli; SALO, Harri; HOeGLUNG, Lisa; KARJALAINEN, Arja; KNUUTTILA, Pia; HOLM, Patrick; RASKU, Sirpa; VESALAINEN, Anniina
Patent: WO2011/51540 A1, 2011 ;
Location in patent: Page/Page column 140-141 ;
WO 2011/051540 A1
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 1 h;
参考文献
WO2006/122200 A1, ;
Page/Page column 47 ;
WO 2006/122200 A1
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; dichloromethane T=-78°C; 2 h; 2: With methanol in tetrahydrofuran; dichloromethane T=20°C;
参考文献
WO2006/120481 A2, ;
Page/Page column 19 ;
WO 2006/120481 A2
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 1 h;
参考文献
WO2006/122200 A1, ;
Page/Page column 47 ;
WO 2006/122200 A1
