3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮合成路线 （共 12 条）
反应条件
potassium tert-butylate in tetrahydrofuran T=0 - 20°C; Cyclization; 3 h;
参考文献
Faul, Margaret M.; Winneroski, Leonard L.; Krumrich, Christine A.
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6053 - 6058
反应条件
in tetrahydrofuran; water T=20°C; Alkylation; 16 h;
参考文献
Faul, Margaret M.; Winneroski, Leonard L.; Krumrich, Christine A.
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6053 - 6058
反应条件
ammonium acetate; potassium hydroxide; sodium hydrogencarbonate; potassium carbonate in methanol; ethanol; water; acetone; toluene
反应条件
1: KOt-Bu / tetrahydrofuran / 0 - 20 °C 2: pyridine 3: dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3841 - 3846
反应条件
1: pyridine 2: dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3841 - 3846
反应条件
1: diethyl ether / 0.5 h / 0 - 5 °C 2: 3.21 g / diethyl ether; methanol / -65 - 20 °C 3: 100 percent / t-BuOK / tetrahydrofuran / 3 h / 0 - 20 °C 4: 99 percent / pyridine / CH2Cl2 / 2.5 h / 20 °C 5: 96 percent / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 17 p. 6053 - 6058
反应条件
1: 82 percent / Dowex 50X8-100 / 1 h / Heating 2: 100 percent / t-BuOK / tetrahydrofuran / 3 h / 0 - 20 °C 3: 99 percent / pyridine / CH2Cl2 / 2.5 h / 20 °C 4: 96 percent / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 17 p. 6053 - 6058
反应条件
1: 3.21 g / diethyl ether; methanol / -65 - 20 °C 2: 100 percent / t-BuOK / tetrahydrofuran / 3 h / 0 - 20 °C 3: 99 percent / pyridine / CH2Cl2 / 2.5 h / 20 °C 4: 96 percent / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 17 p. 6053 - 6058
反应条件
1: 660 mg / conc. HCl / 1 h / Heating 2: 99 percent / pyridine / CH2Cl2 / 2.5 h / 20 °C 3: 96 percent / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 17 p. 6053 - 6058
反应条件
1: KOt-Bu / tetrahydrofuran / 0 - 20 °C 2: pyridine 3: dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3841 - 3846
