potassium carbonate in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
LG LIFE SCIENCES LTD.; KIM, Young Kwan; KIM, Myoung Yeol; PARK, Sang Yun; PARK, Ok Ku; ARTEMOV, Vasily; LEE, Sang Dae; JOO, Hyun Woo; CHOI, Eun Sil
Patent: WO2014/69963 A1, 2014 ;
Location in patent: Paragraph 373-374 ;
1: benzyl alcohol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 1,2-difluoro-4-bromobenzene in tetrahydrofuran T=20°C; 17 h; Further stages. Title compound not separated from byproducts.;
1: bromine; trifluoroacetic acid / 20 °C 2: potassium carbonate / acetonitrile / 15 h / 20 °C View Scheme
参考文献
Givens, Richard S.; Stensrud, Kenneth; Conrad, Peter G.; Yousef, Abraham L.; Perera, Chamani; Senadheera, Sanjeewa N.; Heger, Dominik; Wirz, Jakob
Canadian Journal of Chemistry, 2011 , vol. 89, # 3 p. 364 - 384
tetrakis(triphenylphosphine) palladium(0) in toluene T=100°C; Stille coupling;
参考文献
Givens, Richard S.; Stensrud, Kenneth; Conrad, Peter G.; Yousef, Abraham L.; Perera, Chamani; Senadheera, Sanjeewa N.; Heger, Dominik; Wirz, Jakob
Canadian Journal of Chemistry, 2011 , vol. 89, # 3 p. 364 - 384
hydrogenchloride; n-butyllithium 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, from -78 deg C to RT, 3.) THF, hexane, RT; Yield given. Multistep reaction;
参考文献
Hird, Michael; Goodby, John W.; Toyne, Kenneth J.; Gleeson, Helen F.; Peter Buxton; Seed, Alexander J.; Herbert, Mark R.
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2001 , vol. 365, p. 213 - 220
